Let’s face it, organic chemistry can seem difficult to learn, Application In Synthesis of 2-Aminomalonamide, Especially from a beginner’s point of view. Like 62009-47-6, Name is 2-Aminomalonamide, molecular formula is amides-buliding-blocks, belongs to amides-buliding-blocks compound. In a document, author is Grillo, Alessandro, introducing its new discovery.
In addition to its roles in regulating energy balance and glucose homeostasis, leptin greatly influences hippocampal learning and memory. Because of its tendency to exacerbate autoimmune disease, angiogenesis, and oncogenesis, however, leptin’s usefulness in the treatment of chronic human disease has been severely limited. In the present study, we show that oral delivery of MA-[D-Leu-4]-OB3, a small molecule synthetic peptide leptin mimetic, normalizes glucose utilization and episodic memory in diet-induced obese (DIO) mice, a non-genetic, non-transgenic model of obesity, type 2 diabetes mellitus, and Alzheimer’s Disease (AD)-like cognitive impairment which closely recapitulates human pathology. Oral glucose tolerance and novel object recognition testing indicated that (1) glycemic dysregulation and cognitive impairment are linked in this mouse model; and (2) the ability of MA-[D-Leu-4]-OB3 to normalize glucose utilization systemically appears to be coupled to central effects that are reflected by improvement in episodic memory. Our results suggest that MA-[D-Leu-4]-OB3 may have application not only to the treatment of obesity and diabetes, but also to AD, vascular dementia, mixed dementia, or other forms cognitive impairment which may be associated with the brain’s inability to efficiently utilize glucose and to respond to insulin and insulin-like growth factor (IGF) signaling.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics