Synthetic Route of 7048-04-6, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 7048-04-6, Name is H-Cys-OH.HCl.H2O, SMILES is O=C(O)[C@@H](N)CS.[H]Cl.[H]O[H], belongs to amides-buliding-blocks compound. In a article, author is Wang, Chao, introduce new discover of the category.
This study utilizes Raman spectroscopy to analyze the burn-induced collagen conformational changes in ex vivo porcine skin tissue. Raman spectra of wavenumbers 500-2000 cm(-1) were measured for unburnt skin as well as four different burn conditions: (i) 200 degrees F for 10 s, (ii) 200 degrees F for the 30 s, (iii) 450 degrees F for 10 s and (iv) 450 degrees F for 30 s. The overall spectra reveal that protein and amino acids-related bands have manifested structural changes including the destruction of protein-related functional groups, and transformation from et-helical to disordered structures which are correlated with increasing burn severity. The deconvolution of the amide I region (1580-1720 cm(-1)) and the analysis of the sub-bands reveal a change of the secondary structure of the collagen from the alpha like helix dominated to the beta-aggregate dominated one. Such conformational changes may explain the softening of mechanical response in burnt tissues reported in the literature.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics