90-16-4, A common compound: 90-16-4, name is Benzo[d][1,2,3]triazin-4(3H)-one, belongs to amides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
General procedure: A stirring suspension of 1,2,3-benzotriazin-4-one (6 mmol), 1,2-dibromoethane (18 mmol), potassium carbonate (12 mmol), and acetone (50 ml) was refluxed for 5-8 h and then cooled to room temperature. The reaction mixture was evaporated under reduced pressure, and water (100 mL) was added to the residue, which was extracted with CH2Cl2 (50 mL ¡Á 2). The organic layer was dried over anhydrous Na2SO4, concentrated, and purified with flash chromatography on silica gel, eluting with petroleum ether (60-90C)/EtOAc to afford compound 5 in yield of 62%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Benzo[d][1,2,3]triazin-4(3H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Chen, Xiulei; Jia, Haowu; Li, Zhong; Xu, Xiaoyong; Chinese Chemical Letters; vol. 30; 6; (2019); p. 1207 – 1213;,
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