Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Brandolese, Arianna, once mentioned the application of 98-10-2, Name is Benzenesulfonamide, molecular formula is C6H7NO2S, molecular weight is 157.1903, MDL number is MFCD00007930, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, Name: Benzenesulfonamide.
New anti-hepatocellular injury drugs with better curative effects and fewer side effects are urgently needed at present. In this study, a series of novel N-acetylcysteine (NAC) derivatives were designed, synthesized and biologically evaluated for their anti-hepatocellular injury activities against two different cell models. In the biological evaluation against hydrogen peroxide (H2O2)-induced LO2 hepatocytes, half of the target compounds exhibited moderate to potent activities in improving the model cell viability, and two compounds (6a and 6b) displayed more potent activities in decreasing malondialdehyde (MDA) levels than the positive control NAC. In further 4-acetamidophenol (APAP)-induced LO2 cell experiment, compounds 6a and 6b could not only improve the cell viability but also significantly reduce the secretion of MDA. Additionally, compound 6a displayed excellent Caco-2 permeability and oral bioavailability in rats. All these experimental results suggested that compounds 6a and 6b could serve as potential lead molecules for further development of anti-hepatocellular injury drugs.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 98-10-2, Name: Benzenesulfonamide.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics