Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Formula: https://www.ambeed.com/products/361442-00-4.html, 361442-00-4, Name is (2S)-2-((tert-Butoxycarbonyl)amino)-2-(3-hydroxyadamantan-1-yl)acetic acid, SMILES is CC(C)(C)OC(=O)N[C@H](C(O)=O)C12CC3CC(CC(O)(C3)C1)C2, belongs to amides-buliding-blocks compound. In a document, author is Krishnan, V. V., introduce the new discover.
To get a better understanding on the molecular basis of the cytotoxicity of PEI which has been considered as golden standard for polymeric gene delivery carriers. Dynamic light scattering, fluorescence spectra, zeta. potential measurement and isothermal titration calorimetry were conducted to reveal the mechanism of interaction between PEIs( average molecular weight of 25000, 10000 and 1800) and 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine( DOPC) liposome. The influence on the polarity of microenvironment and the permeability of liposome bilayer were also investigated. The result showed that PEI bound to DOPC vesicles via hydrogen bond or van Waals interactions between the amide groups and the phosphorylcholine heads. The complex formation with PEI induced aggregation and increase in zeta potential of liposomes at low PEI concentration up to 0.075 mg/mL. A further increase in PEI concentration made little change on the sur. face potential, however reduced the aggregation of the vesicle due to the repulsion between the adsorbed PEI chains. PEI binding decreased the packing density of hydrocarbon chain of lipid molecules and the hydropho. bicity in the bilayer membrane, and thus resulted in an enhanced permeability of calcein and quercetin through the membrane. The polymer size played an important role in PEI. DOPC liposome interaction. PEI with higher molecular weight was more favorable to interact with DOPC and more efficient to perturb the structural properties of the membrane.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 361442-00-4. Formula: https://www.ambeed.com/products/361442-00-4.html.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics