In an article, author is Ling, Fei, once mentioned the application of 1638767-25-5, Recommanded Product: 1638767-25-5, Name is tert-Butyl (3-aminobicyclo[1.1.1]pentan-1-yl)carbamate, molecular formula is C10H18N2O2, molecular weight is 198.2621, MDL number is MFCD27987307, category is amides-buliding-blocks. Now introduce a scientific discovery about this category.
We reported the synthesis of new 8-methoxypyrazolo[1,5-a]quinazolines bearing an amide fragment at the 3-position. The final compounds, as aromatic (2a-i) and 4,5-dihydro derivatives (3a-i), have been evaluated in vitro for their ability to modulate the chlorine current on recombinant GABA(A) receptors of the alpha 1 beta 2 gamma 2L type (expressed in frog oocytes of the Xenopus laevis species). From electrophysiological test two groups of compounds emerged: positive modulators agonist (2e, h, i and 3e, h) and null modulators antagonist (2a, b, d, f, g and 3a-d, f, g) of GABA(A) subtype receptor. Using a set of compounds (new derivatives, known products and GABAA subtype receptor ligands from our library) we identify the amino acids at the alpha+/gamma(-) interface, which could be involved in the agonist or antagonist profile, using the ‘Proximity Frequencies’, namely the frequencies with which a ligand intercepts two or more binding-site amino acids during the molecular dynamic simulation. The linear discriminant analysis (LDA) evidences that the combination of amino acids alpha VAL203- gamma THR142 and alpha TYR 160-gamma TYR 58 allowed to collocate 70.6% of agonists and 72.7% of antagonists in their respective class.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics