A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 33045-52-2, Name is Methyl 2-methoxy-5-sulfamoylbenzoate, molecular formula is C9H11NO5S. In an article, author is Chae, Chang-Geun,once mentioned of 33045-52-2, SDS of cas: 33045-52-2.
The area of covalent inhibitors is gaining momentum due to recently introduced clinical drugs, but libraries of these compounds are scarce. Multicomponent reaction (MCR) chemistry is well known for its easy access to a very large and diverse chemical space. Here, we show that MCRs are highly suitable to generate libraries of electrophiles based on different scaffolds and three-dimensional shapes and highly compatible with multiple functional groups. According to the building block principle of MCR, acrylamide, acrylic acid ester, sulfurylfluoride, chloroacetic acid amide, nitrile, and alpha,beta-unsaturated sulfonamide warheads can be easily incorporated into many different scaffolds. We show examples of each electrophile on 10 different scaffolds on a preparative scale as well as in a high-throughput synthesis mode on a nanoscale to produce libraries of potential covalent binders in a resource-and time-saving manner. Our operational procedure is simple, mild, and step economical to facilitate future covalent library synthesis.
Interested yet? Keep reading other articles of 33045-52-2, you can contact me at any time and look forward to more communication. SDS of cas: 33045-52-2.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics