New downstream synthetic route of tert-Butyl (2-(2-aminoethoxy)ethyl)carbamate

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127828-22-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127828-22-2, name is tert-Butyl (2-(2-aminoethoxy)ethyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows.

6.3g of compd 42 and 2.Og of 2-bromohypoxanthine were dispersed in 55ml monomethoxyethanol and 17.5ml water. The reaction mixture was stirred at reflux for 16h, and the solvent was removed under reduced pressure. Then the concentrate was stirred in 20ml MC and 10ml water for 30 min, and the resulting precipitate was collected by filtration to obtain 2.1g of compd 43 as a pale yellow solid. 1H NMR (500MHz; DMSOd6) delta 12.43 (br s, IH), 10.45 (br s, IH), 7.89 (s, 0.2H), 7.61 (s, 0.8H), 6.77 (m, IH), 6.34 (s, 0.8H), 6.12 (s, 0.2H), 3.52 (t, 2H), 3.41 (m, 4H), 3.09 (q, 2H), 1.36 (s, 9H).

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Reference:
Patent; CTI BIO; WO2009/113828; (2009); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics