A common heterocyclic compound, 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide, molecular formula is C10H15NO2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 6292-59-7.
A mixture of 4-teritary butyl benzene sulfonamide (15.2 grams) having 0.11percent of 4-isopropyl benzene sulfonamide, potassium carbonate (19.77 grams), tetrabutylammonium bromide (0.7 grams) in toluene (750 ml) was heated to 45-50¡ãC and stirred for 30 minutes.4,6-dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine (25 grams) was added the above mixture and heated to reflux temperature then stirred for 12 hours. The reaction mixture was cooled and then quenched with water. The reaction mixture was filtered and washed the solid with water. Acetonitrile (300 ml) was added to wet solid and heated to reflux temperature then stirred for 2 hours. Water (50 ml) was added to the above wet solid and acidified with hydrochloric acid. The solid was filtered, washed with water and dried to get the title compound.Yield: 80 grams; Purity by HPLC: 98.97 percent; isopropyl derivative: 0.11percent
The synthetic route of 4-(tert-Butyl)benzenesulfonamide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; VENKAT REDDY, Ghojala; WO2011/21216; (2011); A2;,
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