49805-30-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 49805-30-3, name is 2-Azabicyclo[2.2.1]hept-5-en-3-one belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
1.7. Preparation of (+-)-1-amino-4-(hydroxymethyl)-2-cyclopentene in the presence of additives such as water or various alcohols A 10 ml round-bottom flask was charged with 0.50 g (4.66 mmol) of (+-)-2-azabicyclo[2.2.1]hept-5-en-3-one and 0.30 g (13.7 mmol) of lithium borohydride in 7.5 ml of abs. dioxane, and the mixture was heated to 60 C. At this temperature, over the course of 30 min, X mmol of alcohol Y was added dropwise using a syringe. The mixture is then stirred for 2 h at 60 C., cooled to about 20 C. and poured into about 10 ml of semi-concentrated HCl. The content was then determined directly using a quantitative ion-chromatographic method (cf.
The synthetic route of 2-Azabicyclo[2.2.1]hept-5-en-3-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Lonza AG; US2002/10360; (2002); A1;,
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