563-83-7, The chemical industry reduces the impact on the environment during synthesis 563-83-7, name is Isobutyramide, I believe this compound will play a more active role in future production and life.
A solution of 2-methylpropanamiotade (6 53 g, 75 0 mmol) and 2,4-biotas(4- methoxyphenyl)-1 ,3-diotathiotaa-2,4-diotaphosphetane-2,4-diotasulfiotade (15 17 g, 37 51 mmol) in THF (100 mL) was heated to reflux for 4 h The reaction mixture was then cooled to rt and poured into saturated aqueous NaHCO3 (200 mL) The mixture was extracted with ether (4 x 100 mL) The organic fractions were combined, dried over Na2SO4, filtered, and concentrated Purification by flash column chromatography (20% EtOAc hexanes) afforded 4 77 g (62%) of the title compound of Step A 1H-NMR (400 MHz, CDCI3) delta 7 63 (brs, 1 H), 6 90 (brs, 1 H), 2 88 (m, 1 H), and 1 27 (d, 6H, J = 6 8 Hz)
The chemical industry reduces the impact on the environment during synthesis Isobutyramide. I believe this compound will play a more active role in future production and life.
Reference:
Patent; GLAXOSMITHKLINE LLC; ADJABENG, George; BAUM, Erich; BIFULCO, Neil; DAVIS-WARD, Ronda, G.; DICKERSON, Scott, Howard; DONALDSON, Kelly, Horne; HORNBERGER, Keith; PETROV, Kimberly; RHEAULT, Tara, Renae; SAMMOND, Douglas, McCord; SCHAAF, Gregory, M.; STELLWAGEN, John; UEHLING, David, Edward; WATERSON, Alex, Gregory; WO2010/104899; (2010); A1;,
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