6292-59-7, Adding a certain compound to certain chemical reactions, such as: 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6292-59-7.
Example 3: Preparation of propionic acid 2-[6-(4-tert-butyl-benzenesulfonylamino)-5- (2-methoxy-phenoxy)-[2, 2′] bipyrimidinyl-4-yloxy]-ethyl ester compound of formula IV.A mixture of 4-tert butyl benzene sulfonamide (49.5g, 1eq), Potassium phosphate (123.8g, 2.5eq) dimethyl acetamide (500ml, 5vol) was heated to 40¡ãC and maintained for 30-60 minutes. Propionic acid 2-[6-chloro-5-(2-methoxy-phenoxy)-[2,2′] bipyrimidinyl-4-yloxy]-ethyl ester of formula V (100g, 1 eq) was added to the reaction mixture and the reaction mass was heated to 90¡ãC for 24-28 hours. Filtered the inorganic solid and washed the solid with dimethyl acetamide (100ml, 1vol). To the mixture of water (2.5L, 25vol) and concentrated hydrochloric acid (150ml, 1.5Vol) was added the filtrate at 0-5¡ãC. Maintained the stirring for 1-2 hours at 0-5¡ãC .Filtered the solid and washed with water (500ml, 5vol). Dissolved the wet cake in DCM (500ml, 5Vol) and added to a mixture of water (700ml,7vol) and concentrated hydrochloric acid (75ml, 0.75vol) at 10-15¡ãC.Stirred, separated the DCM layer and repeated the washing with mixture of water (700ml, 7vol) and concentrated hydrochloric acid (75ml, 0.75vol) at 10-15¡ãC. Separated the DCM layer and washed with water (500ml, 5vol). Distilled DCM under vacuum at 35-40¡ãC to get title compound (yield 110g, HPLC purity- 85percent).
According to the analysis of related databases, 6292-59-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MATRIX LABORATORIES LTD; GORE, Vinayak; BINDU, Manojkumar; SHINDE, Dattatraya; KOKANE, Dattatrey; GHRAT, Sushant; DANDALA, Ramesh; WO2012/56468; (2012); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics