Chemistry is an experimental science, Computed Properties of https://www.ambeed.com/products/123-39-7.html, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 123-39-7, Name is N-Methylformamide, molecular formula is C2H5NO, belongs to amides-buliding-blocks compound. In a document, author is Hu, Qiyan.
The linear tridentate sp(3)P/sp(3)NH/sp(2)N ligand PN(H)N ((R)-2′-(diphenylphosphino)-N-(pyridin-2-ylmethyl)[1,1′- binaphthalen]-2-amine) exclusively forms fac[Ru(PN(H)N)(dmso)(3)](BF4)(2) over the mer isomer with the help of the three strongly pi-accepting DMSO ligands. The three different ligating atoms exert a divergent effect on the trans-DMSO Ru bond strengths, enabling the stereo selective generation of fac-RuH(CH3O)(PN(H)N)(dmso) (RuNH). RuNH efficiently hydrogenates both nonchelatable t-butyl methyl ketone (BMK) and chelatable t-butyl methoxycarbonylmethyl ketone (BMCK) in the presence of a catalytic amount of CH3OK. The reaction proceeds at the H-sp(3)N-Ru-H bifunctional reaction site of fac-RuH2(PN(H)N)(dmso), and high enantioselectivity is attained in a chiral 3D cavity constructed by the sp(3)N trans DMSO, the conformation of which is fixed by a PyC(6)H-O=S hydrogen bond. We determined the structures of RuNH, the K amide RuNK, Ru dihydride, and Ru amido species by detailed NMR analysis using N-15-labeled PN(H)N and C(3)-Ph-substituted PN(H)N. The rate of BMK hydrogenation is significantly affected by [CH3OK](0), showing a characteristic curve with a peak followed by a pseudo-minus-first-order decay. The RuNH is easily deprotonated by CH3OK to generate RuNK, which is less reactive but has the same enantioface discrimination ability. Increased contribution of the slow RuNK cycle decreases the rate at higher [CH3OK](0). The RuNH- and RuNK-involved dual catalytic cycle is supported by curve-fitting analyses and K+ trapping experiments. In hydrogenation of BMCK, only the RuNH cycle operates because BMCK is preferentially deprotonated over RuNH.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 123-39-7, in my other articles. Computed Properties of https://www.ambeed.com/products/123-39-7.html.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics