In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22227-26-5, name is 3,5-Bis(trifluoromethyl)benzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 22227-26-5
General procedure: Benzamide (476 mg, 3.9 mmol) and benzaldehyde(203 mL, 2 mmol) were dissolved in dry DMF (8 mL).TMSCl (507 mL, 4mmol) was added as a catalyst and wasstirred at 50 ¡ãC for 18 h under nitrogen. Awhite precipitatewas formed with the addition of a few drops of water andwas purified by stirring with diethyl ether for 30 min. Theproduct was isolated using vacuum filtration. Yield 31percent
The synthetic route of 22227-26-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Clarke, Harriet J.; Van Rossom, Wim; Horton, Peter N.; Light, Mark E.; Gale, Philip A.; Supramolecular Chemistry; vol. 28; 1-2; (2016); p. 10 – 17;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics