Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 11-Aminoundecanoic acid, 2432-99-7, Name is 11-Aminoundecanoic acid, SMILES is NCCCCCCCCCCC(O)=O, belongs to amides-buliding-blocks compound. In a document, author is Maity, Sandeepan, introduce the new discover.
Coordination, redox properties and SOD activity of Cu(II) complexes of multihistidine peptides
The results of electrochemical and SOD activity measurements of such copperal) complexes of terminally protected multihistidine peptides that may mimic the active site of CuZnSOD enzyme are submitted and completed with solution equilibrium studies of some copper(II)-ligand systems. The equilibrium data confirm that the thermodynamic stabilities increase with the increasing number of histidyl residues in the amino acid sequence, the stability order, however, can be finely tuned by the number and quality of amino acids between histidine residues. Based on the cyclic voltammetric studies we concluded that the formal reduction potential values of imidazole nitrogen coordinated complexes decrease with the increasing number of imidazole donor atoms in the coordination sphere. However, the redox parameters of [CuH-1L](+) and [CuH-2L] complexes containing amide nitrogen coordination can be determined as well. All formal potential values of [CuL](2+) [CuH-1L](+) and [CuH-2L] complexes fall in the middle potential range of SOD activity. Finally, after the detailed analysis of species distribution curves based upon the equilibrium data SOD activity of copper(II) containing systems at two pH (pH = 6.8 and 7.4) were determined. The imidazole coordinated [CuL](2+) complexes of the multihistidine peptide containing the HXH sequence exhibit the most significant activity, but the presence of amide nitrogen coordinated species with slightly distorted geometry could considerably contribute to the SOD activity.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2432-99-7. Recommanded Product: 11-Aminoundecanoic acid.