Let’s face it, organic chemistry can seem difficult to learn, Product Details of 3493-12-7, Especially from a beginner’s point of view. Like 3493-12-7, Name is DL-Methionine Methylsulfonium Chloride, molecular formula is amides-buliding-blocks, belongs to amides-buliding-blocks compound. In a document, author is Sun, Yue, introducing its new discovery.
Synthesis of 2-ethoxycarbonylthieno[2,3-b]quinolines in biomass-derived solvent gamma-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B
A series of 2-ethoxycarbonylthieno[2,3-b]quinolines were synthesized in the bio-derived green solvent gamma-valerolactone (GVL) and evaluated for their inhibitory activities against PTP1B, the representative compound 6a displayed an IC50 value of 8.04 +/- 0.71 mu M with 4.34-fold preference over TCPTP. These results provided novel lead compounds for the design of inhibitors of PTP1B as well as other PTPs.
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