The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 98-79-3, Name is H-Pyr-OH, SMILES is O=C([C@H](CC1)NC1=O)O, in an article , author is Chen, Dong-Huang, once mentioned of 98-79-3, Recommanded Product: 98-79-3.
Synthesis of 3-Hydroxy-3-heterocyclebutylamide Derivatives Using Carbamoylsilanes as an Amide Source
3-Hydroxy-3-heterocyclebutyl amide derivatives were directly synthesized in 56%similar to 85% yields by nucleophilic addition of various carbamoylsilanes to oxetane-3-one or thietane-3-one in toluene under mild and catalyst-free conditions. This method will provide an efficient route for the synthesis of drugs containing four-membered heterocycles which have not additional stereocentres. The procedure can prepare 3-hydroxy-3-heterocyclebutyl tertiary, secondary and primary amides as well as having a stereocentre connecting with nitrogen atom by selecting different carbamoylsilanes. A comparison of the results obtained from reaction of various carbamoylsilanes indicated that the size of group on the amide group was an important factor in the addition reaction, which influenced on both the reaction time and yields. The reaction has the advantages of mild conditions, less by-products, good yield and simple post-treatment, and is a new method for the efficient preparation of 3-hydroxy-3-heterocycle butylamides.
Interested yet? Read on for other articles about 98-79-3, you can contact me at any time and look forward to more communication. Recommanded Product: 98-79-3.