Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 14433-76-2, Name is N,N-Dimethylcapramide, SMILES is CCCCCCCCCC(N(C)C)=O, in an article , author is Sokolov, V. B., once mentioned of 14433-76-2, COA of Formula: C12H25NO.
Unified Approach to the Chemoselective alpha-Functionalization of Amides with Heteroatom Nucleophiles
Functionalization at the alpha-position of carbonyl compounds has classically relied on enolate chemistry. As a result, the generation of a new C-X bond, where X is more electronegative than carbon requires an oxidation event. Herein we show that, by rendering the alpha-position of amides electrophilic through a mild and chemoselective umpolung transformation, a broad range of widely available oxygen, nitrogen, sulfur, and halogen nucleophiles can be used to generate alpha-functionalized amides. More than 60 examples are presented to establish the generality of this process, and calculations of the mechanistic aspects underline a fragmentation pathway that accounts for the broadness of this methodology.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 14433-76-2, you can contact me at any time and look forward to more communication. COA of Formula: C12H25NO.