Application of 146374-27-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 146374-27-8, Name is 2-Methylpropane-2-sulfinamide, SMILES is CC(C)(C)[S](=O)N, belongs to amides-buliding-blocks compound. In a article, author is Rodriguez-Corvera, C. L., introduce new discover of the category.
Synthesis of Mepivacaine and Its Analogues by a Continuous-Flow Tandem Hydrogenation/Reductive Amination Strategy
Herein we report a convenient, fast, and high-yielding method for the generation of the racemic amide anaesthetics mepivacaine, ropivacaine, and bupivacaine. Coupling of -picolinic acid and 2,6-xylidine under sealed-vessel microwave conditions generates the intermediate amide after a reaction time of only 5 min at 150 degrees C. Subsequent reaction in a continuous-flow high-pressure hydrogenator (H-Cube Pro(TM)) in the presence of the respective aldehyde directly converts the intermediate to the final amide anaesthetics in a continuous, integrated, multi-step ring-hydrogenation/reductive amination protocol. Merits and limitations of the protocol are discussed.
Application of 146374-27-8, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 146374-27-8 is helpful to your research.