Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 830-43-3, name is 4-(Trifluoromethyl)benzenesulfonamide, This compound has unique chemical properties. The synthetic route is as follows., 830-43-3
Combine p-trifluoromethylbenzenesulfonamide (112.6 mg, 0.5 mmol), iridium catalyst (5.1 mg, 0.005 mmol, 1 mol%), potassium hydroxide (28 mg, 0.5 mmol, 1 equiv), and methanol (0.3 mL), water (0.9 mL) was sequentially added to the reaction vessel. After the reaction mixture was reacted at 130 C for 12 hours in a reaction vessel, it was cooled to room temperature. The solvent was removed by rotary evaporation, and then the purified target compound was obtained by column chromatography (developing solvent: petroleum ether / ethyl acetate), yield: 90%.
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Reference:
Patent; Nanjing University of Science and Technology; Meng Chong; Tang Yawen; Li Feng; (10 pag.)CN110857278; (2020); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics