The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 57-00-1, Name is 2-(1-Methylguanidino)acetic acid, SMILES is O=C(O)CN(C)C(N)=N, in an article , author is Nadarajah, Sri Kumaran, once mentioned of 57-00-1, Formula: C4H9N3O2.
Competition between the donor and acceptor hydrogen bonds of the threads in the formation of [2] rotaxanes by clipping reaction
The synthesis of benzylic amide [2] rotaxanes using 1,2-bis(aminocarbonyl-(1′-tert-butyl-1H-pyrazole-[3′] 5′-yl))-ethanes as templates is reported. These templates are equipped with tert-butyl pyrazole-based stoppers and have donor (N-H) and acceptor (C=O) hydrogen bond groups. The synthesis of [2] rotaxanes has been shown to be highly dependent on the tert-butylpyrazole stoppers. While the thread with 10,30-disubstituted pyrazoles as stopper units was shown to be an excellent template for the synthesis of [2] rotaxanes, the thread with 1′,5′-disubstituted pyrazoles as stopper units did not yield the expected [2] rotaxane. The structure of the synthesized [2] rotaxanes was characterized using NMR experiments and X-ray diffraction, with the latter showing that the macrocycle adopts a distorted chair conformation. An in-depth study of the isolated thread’s X-ray structures and concentration-dependent NMR experiments seem to explain the dependence of the rotaxane formation on the substitution pattern of the thread’s pyrazole stoppers.
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