Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 5977-14-0, Name is Acetoacetamide, molecular formula is C4H7NO2, belongs to amides-buliding-blocks compound. In a document, author is Qiu, Min, introduce the new discover, Product Details of 5977-14-0.
Design, synthesis and antiproliferative effect of 17 beta-amide derivatives of 2-methoxyestradiol and their studies on pharmacokinetics
A series of 17 beta-amide-2-methoxyestradiol compounds were synthesized with an aim to enhance the anti proliferative effect of 2-methoxyestradiol. The antiproliferative activity of 2-methoxyestradiol analogs against human cancer cells was investigated. 2-methoxy-3-benzyloxy-17 beta-chloroacetamide-1,3,5(10)-triene (5e) and 2-methoxy-3-hydroxy-1713-butyramide-1,3,5(10)-triene (6c) had comparable or better antitumor activity than 2-methoxyestradiol. The elimination half-life of 6c (t(1/2 beta) = 240.93 min) is ten times longer than 2-ME and the area under the curve was seven times (AUC(0-tmin) = 2068.20 +/- 315.74 lig mL(-1) min) higher than 2-ME, respectively. Whereas 5e had similar pharmacokinetic behavior with 2-ME (t(1/2 beta) = 22.28 min) with a t(1/2 beta) of 29.5 min. 6c had higher blood concentration, longer actuation duration and better suppression rate against 5180 mouse ascites tumor than 2-methoxyestradiol.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 5977-14-0. Product Details of 5977-14-0.