One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 122-07-6, Name is 2,2-Dimethoxy-N-methylethanamine, formurla is C5H13NO2. In a document, author is Zou, Yun-Xiang, introducing its new discovery. Recommanded Product: 2,2-Dimethoxy-N-methylethanamine.
[F-18]Fluorophenylazocarboxylates: Design and Synthesis of Potential Radioligands for Dopamine D3 and mu-Opioid Receptor
F-18-Labeled building blocks from the type of [F-18]fluorophenylazocarboxylic-tert-butyl esters offer a rapid, mild, and reliable method for the F-18-fluoroarylation of biomolecules. Two series of azocarboxamides were synthesized as potential radioligands for dopamine D3 and the mu-opioid receptor, revealing compounds 3d and 3e with single-digit and sub-nanomolar affinity for the D3 receptor and compound 4c with only micromolar affinity for the mu-opioid receptor, but enhanced selectivity for the mu-subtype in comparison to the lead compound AH-7921. A minimalist procedure without the use of a cryptand and base for the preparation of 4[F-18] fluorophenylazocarboxylic-tert-butyl ester [F-18]2a was established, together with the radiosynthesis of methyl-, methoxy-, and phenyl-substituted derivatives ([F-18]2b-f). With the substituted [F-18] fluorophenylazocarbylates in hand, two prototype azocarboxylates radioligands were synthesized by F-18-fluoroarylation, namely the methoxy azocarboxamide [F-18]3d as the D3 receptor radioligand and [F-18]4a as a prototype structure of the mu-opioid receptor radioligand. By introducing the new series of [F-18] fluorophenylazocarboxylic-tert-butyl esters, the method of F-18-fluoroarylation was significantly expanded, thereby demonstrating the versatility of F-18-labeled phenylazocarboxylates for the design of potential radiotracers for positron emission tomography.
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