108468-00-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 108468-00-4, name is 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene, A new synthetic method of this compound is introduced below.
820 mg of tert-butyl N-[[4-(aminomethyl)-phenyl]-methyl]-carbamate and 421 mg of TEA was dissolved in 10 mL of DCM, cooled in an ice bath and 725 mg of thioacetic acid S-(4-chlorocarbonyl-phenyl) ester, dissolved in 5 mL of DCM, was slowly added. The mixture obtained was stirred for 30 min at rt, the phases were separated, the organic phase obtained was washed successively with 2N HCl and 5% aqueous NaHCO3 solution, dried over Na2SO4 and evaporated to dryness. The title compound was obtained in the form of pale brown crystals.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; NABRIVA THERAPEUTICS AG; Thirring, Klaus; Heilmayer, Werner; Riedl, Rosemarie; Kollmann, Hermann; Ivezic-Schoenfeld, Zrinka; Wicha, Wolfgang; Paukner, Susanne; Strickmann, Dirk; (90 pag.)US2016/332963; (2016); A1;,
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