Adding some certain compound to certain chemical reactions, such as: 1122-56-1, name is Cyclohexanecarboxamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1122-56-1. 1122-56-1
General procedure: The benzamide (0.2 mmol), NaH (3 equivalents) and dry THF(3 mL) were added to a two-neck flask in turn and stirred atroom temperature for 1 h. Then disulfide (1.5 equivalent) wasadded into the mixture and stirred for another 36 h at roomtemperature. During the whole reaction process, the systemwas kept turbid because of the difficult solubility of NaH inTHF. Then the resulting mixture was filtered and washed withEtOAc to give the solvent, which was concentrated in vacuoand the residue was purified by flash column chromatographyon a silica gel to give the desired product
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Cyclohexanecarboxamide.
Reference:
Article; Zhang, Xing-Song; Zhang, Xiao-Hong; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 1; (2016); p. 89 – 94;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics