Electric Literature of 361442-00-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 361442-00-4, Name is (2S)-2-((tert-Butoxycarbonyl)amino)-2-(3-hydroxyadamantan-1-yl)acetic acid, SMILES is CC(C)(C)OC(=O)N[C@H](C(O)=O)C12CC3CC(CC(O)(C3)C1)C2, belongs to amides-buliding-blocks compound. In a article, author is Lu, Kangyi, introduce new discover of the category.
Base-Mediated 1,6-Aza-Michael Addition of Heterocyclic Amines and Amides to para -Quinone Methides Leading to Meclizine-, Hydroxyzine- and Cetirizine-like Architectures
An expeditious, cost-effective synthetic methodology for a wide range of nitrogen-containing unsymmetrical trisubstituted methanes (TRSMs) is reported. The synthesis involves base-mediated 1,6-conjugate addition of heterocyclic amines and amides to substituted para -quinone methides, giving the unsymmetrical TRSMs in moderate to very good yields (up to 83%) in one pot. The low cost, mild temperature, high atom economy and yields, easy scale-up and broad substrate scope are some of the salient features of this protocol. Further, the methodology could be extended for the synthesis of meclizine-, -hydroxyzine- and cetirizine-like molecules. The structure of one such compound, 2,6-di- tert -butyl-4-((4-chlorophenyl)(4-methylpiperazin-1-yl)methyl)phenol, was determined by single crystal X-ray analysis.
Electric Literature of 361442-00-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 361442-00-4 is helpful to your research.