Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 88829-82-7, name is tert-Butyl (8-aminooctyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows., 88829-82-7
To a solution of 5-((S)-l-cyclohexyl-2-((S)-l-((l S,3aR,6aS)-l-((S)-l-(cyclopropylamino)- l,2-dioxohexan-3-ylcarbamoyl)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)-3,3-dimethyl-l-oxobutan- 2-ylamino)-2-oxoethylcarbamoyl)pyrazine-2-carboxylic acid (120 mg, 0.166 mmol) and tert-butyl 8- aminooctylcarbamate (40.6 mg, 0.166 mmol) in DMF (1 mL), DIEA (107 mg, 0.83 mmol), HATU (126 mg, 0.332 mmol) and HOAt (4.5 mg, 0.0332 mmol) were added at 0C. The reaction was stirred for 10 minutes. The reaction mixture was purified with HPLC to get tert-butyl 8-(5-((S)-l- cyclohexyl-2-((S)- 1 -(( 1 S,3 aR,6aS)- 1 -((S)- 1 -(cyclopropylamino)- 1 ,2-dioxohexan-3 – ylcarbamoyl)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)-3,3-dimethyl-l-oxobutan-2-ylamino)-2- oxoethylcarbamoyl)pyrazine-2-carboxamido)octylcarbamate. The residue was dissolved in DCM (1 mL), and then TFA (1 mL) was added to the solution. The mixture was stirred at room temperature for 1 hour. The solvent was evaporated under vacuum to get the crude product N2-(8- aminooctyl)-N5-((S)-l-cyclohexyl-2-((S)-l-((l S,3aR,6aS)-l-((S)-l-(cyclopropylamino)-l,2- dioxohexan-3-ylcarbamoyl)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)-3,3-dimethyl-l-oxobutan-2- ylamino)-2-oxoethyl)pyrazine-2, 5-dicarboxamide TFA salt (141 mg, 0.15 mmol, 90%) without any further purification. LC/MS m/z calculated for [M+H]+ 850.5, found 850.5.
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Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; GRAY, Nathanael S.; ZHANG, Tinghu; YANG, Priscilla; DE WISPELAERE, Melissanne; DU, Guangyan; (144 pag.)WO2020/69125; (2020); A1;,
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