The chemical industry reduces the impact on the environment during synthesis 177906-48-8, name is trans-N-Boc-1,4-cyclohexanediamine, I believe this compound will play a more active role in future production and life. 177906-48-8
Intermediate 46; N-(5-lodo-imidazo[2,1 -b][1 ,3,4]thiadiazol-2-yl)-N’,N’-dimethyl-irans- cyclohexane-1,4-diamine; Step 1 : (4-Dimethylamino-irans-cyclohexyl)-carbamic acid tert-butyl ester; A solution of N-boc-frans-1 ,4-cyclohexanediamine (1 g, 4.7 mmol, 1 equiv) and formaldehyde (1.39 ml, 18.7 mmol, 4 equiv) was treated with sodium cyanoborohydride (0.926 g, 14 mmol, 3 equiv) and then with acetic acid (1.6 ml, 28 mmol, 6 equiv). The reaction mixture was stirred at room temperature under argon atmosphere overnight. The solvent was removed under reduced pressure, and the crude was suspended in sat. NaHC03 and extracted with dichloromethane. The organic layer was dried over Na2S04, filtered and concentrated to afford the desired product (0.787 g) which was used in the next step of the synthesis without further purification.
The chemical industry reduces the impact on the environment during synthesis 177906-48-8. I believe this compound will play a more active role in future production and life.
Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; KURZ, Guido; RICO FERREIRA, Maria del Rosario; SOILAN RODRIGUEZ, David; ORTEGA SORET, Miguel Angel; LINK, Wolfang; RABAL GRACIA, Obdulia; WO2012/20215; (2012); A1;,
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