The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 600-21-5, Name is H-N-Me-DL-Ala-OH, SMILES is CC(NC)C(O)=O, in an article , author is Chon, Bonghwan, once mentioned of 600-21-5, Application In Synthesis of H-N-Me-DL-Ala-OH.
Design and synthesis of biaryloxazolidinone derivatives containing amide or acrylamide moiety as novel antibacterial agents against Gram-positive bacteria
A series of novel biaryloxazolidinone derivatives containing amide and acrylamide structure were designed, synthesized and evaluated for their antibacterial activity. Most compounds generally exhibited potent antibacterial activity with MIC values of 1 mu g/mL against S. aureus, MRSA, MSSA, LREF and VRE pathogens, using linezolid and radezolid as positive controls. Compound 17 exhibited good antibacterial activity with MIC values of 0.5 mu g/mL against S. aureus, MRSA, MSSA and VRE and 0.25 mu g/mL against LREF. The results indicated that compound 17 might serve as a potential hit-compound for further investigation.
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