In an article, author is Hua, Lap-Cuong, once mentioned the application of 6027-13-0, Formula: C4H9NO2S, Name is (S)-2-Amino-4-mercaptobutanoic acid, molecular formula is C4H9NO2S, molecular weight is 135.1848, MDL number is MFCD00151320, category is amides-buliding-blocks. Now introduce a scientific discovery about this category.
Twisted N-Acyl-hydantoins: Rotationally Inverted Urea-Imides of Relevance in N-C(O) Cross-coupling
We report a combined structural and computational study on the properties of twisted acyclic hydantoins. These compounds feature cyclic urea-imide moiety that is widely found in bioactive compounds and is structurally related to the classic bridged hydantoins proposed by Smissman more than 50 years ago. We demonstrate that C to N-substitution of the imide moiety in the succinimide ring to give hydantoin results in one of the most distorted acyclic amide bonds reported to date. The energetic properties of twisted acyclic hydantoins with respect to structures, resonance energies, barriers to rotation, and proton affinities are discussed. The energetic and structural properties of twisted acyclic hydantoins described provide a benchmark to facilitate the development of twisted amides based on the biorelevant cyclic urea-imide scaffold.
If you are interested in 6027-13-0, you can contact me at any time and look forward to more communication. Formula: C4H9NO2S.