In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1120-16-7, name is Dodecanamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 1120-16-7
In order to gain a deeper insight into the structure activity relationship, a battery of 15 additional bisphosphonates were synthesized harbouring different functional groups at the alpha-carbon and displaying lipid-tails of different length, respectively (Scheme 1). Scheme 1. Synthesis of bisphosphonates. Reagents and conditions: a) NaH, Toluene, 60 C, 16 h b) HCI, reflux, 16 h c) P(OMe)3, 0 C, 2 h d) HP(OMe)2, nBu2NH, 0 C, 16 h e) H3PO3, MsOH, then PCl3, 90 C, 16 h f) PCl3/H3PO3, 70C, 12 h, then H2O, 2h
The synthetic route of 1120-16-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Humboldt Universitaet zu Berlin; Rheinisch-Westfaelische Technische Hochschule Aachen (RWTH); EP2289900; (2011); A1;,
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