In an article, author is Nobre, Sabrina M., once mentioned the application of 2835-81-6, COA of Formula: C4H9NO2, Name is H-DL-Abu-OH, molecular formula is C4H9NO2, molecular weight is 103.12, MDL number is MFCD00008093, category is amides-buliding-blocks. Now introduce a scientific discovery about this category.
Traceless solid-phase synthesis and beta-turn propensity of 1,3-thiazole-based peptidomimetics
The design and solid-phase synthesis of 1,3-thiazole-based peptidomimetic molecules is described. The solid-phase synthesis was based on the utilization of a traceless linker strategy. The synthesis starts from the conversion of chloromethyl polystyrene resin to the resin with a sulfur linker unit. The key intermediate 4-amino-thiazole-5-carboxylic acid resin is prepared in three steps from Merrifield resin. The amide coupling proceeded at the C4 and C5 positions via an Fmoc solid-phase peptide synthesis strategy. After cleavage, the final compounds were obtained in moderate yields (average 9%, 11-step overall yields) with high purities (>= 87%). Geometric measurements of C alpha distances and dihedral angles along with an rmsd of 0.5434 for attachment with C alpha of the beta-turn template suggest type IV beta-turn structural motifs. Additionally, the physicochemical properties of the molecules have been evaluated.
If you are interested in 2835-81-6, you can contact me at any time and look forward to more communication. COA of Formula: C4H9NO2.