As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 630-22-8 name is 2,2-Dimethylpropanethioamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 630-22-8
General procedure: To a suspension of different thioamides 1b, 2b, 3b (7.28 mmol)in ethyl alcohol (15 mL) was added at room temperature ethyl 2-chloroacetoacetate (1 equiv.). The solution was refluxed for 24 h,and then the solvent was removed under reduced pressure. Thesolid material was washed with cooled hexane (2 10 mL) to givethe corresponding pure ethyl carboxylate derivatives 1c, 2c, 3c indifferent yields. Ethyl 2-(tert-butyl)-4-methylthiazole-5-carboxylate (1c).Prepared from 2,2-dimethyl propanthioamide (1b). Yellow solid75.3%; mp: 43e47 C [40].
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2-Dimethylpropanethioamide, and friends who are interested can also refer to it.
Reference:
Article; Ghonim, Aya E.; Ligresti, Alessia; Rabbito, Alessandro; Mahmoud, Ali Mokhtar; Di Marzo, Vincenzo; Osman, Noha A.; Abadi, Ashraf H.; European Journal of Medicinal Chemistry; vol. 180; (2019); p. 154 – 170;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics