In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 85006-25-3, name is tert-Butyl (tert-butoxycarbonyl)oxycarbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 85006-25-3
To a suspension of sodium hydride (60% in mineral oil, 10 mg, 0.250 mmol) in 0.5 mL of DMF , N,O-diBoc-hydroxylamine (55.6 mg, 0.230 mmol) was added. The mixture was stirred for 30′ at 0C then a solution of 3-[3′- Adamantan-1 -yl-4′-(2-bromo-ethoxy)-biphenyl-4-yl]-acrylic acid ferf-butyl ester (103 mg, 0.192 mmol) in 2 mL of DMF was slowly added. After having stirred at room temperature overnight, DMF was evaporated, the residue was poured into saturated solution of NH4CI and extracted with ethyl acetate. The organic phase was dried and evaporated. Purification by flash chromatography (Hexane/Ethyl acetate 90:10) gave 109 mg (81 %) of the desired compound as white solid; m.p. 165C, Rf(Hexane/Ethyl acetate 90:10) 0.26.1H-NMR (300 MHz, CDCI3) delta:7.61 (1 H, d, J = 16.1 Hz); 7.57.7.50 (4H, m); 7.47 (1 H, d, J = 2.21 Hz); 7.39 (1 H, dd, J = 8.46, 2.21 Hz); 6.93 (1 H, d, J = 8.46 Hz); 6.38 (1 H, d, J = 16.1 Hz); 4.27-4.17 (2H, m); 4.16-4.01 (2H, m); 2.22-2.02 (9H, m), 1 .86- 1 .70 (6H, m), 1 .54 (9H, s); 1 .52 (9H, s); 1.49 (9H, s).
The synthetic route of 85006-25-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOGEM S.CA.R.L.; PISANO, Claudio; DALLAVALLE, Sabrina; CINCINELLI, Raffaella; MERLINI, Lucio; (56 pag.)WO2018/60354; (2018); A1;,
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