In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2895-21-8, name is N-Isopropyl-2-chloroacetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 2895-21-8
(2) To a solution of the compound 2 (112 mg) in dichloromethane (2 mL) was added trifluoroacetic acid (2 mL), andthe reaction mixture was stirred for 1 hour at room temperature. The reaction mixture was diluted with methanol,then the solution was treated with packed strong cation exchange resin (PoraPak Rxn Cx, eluent: a solution of 1mol/L NH3 in methanol), and the eluate was concentrated under reduced pressure. The resulting residue, thecompound 3 (82 mg) and sodium carbonate (64 mg) were suspended in acetonitrile (3 mL), and the suspensionwas stirred for 19 hours at 65 C under argon atmosphere. The reaction mixture was cooled to room temperature,diluted with chloroform, and then washed with water, and dried over anhydrous sodium sulfate. The solvent wasevaporated under reduced pressure, and the resulting residue was purified by silica gel column chromatography(eluent: hexane-ethyl acetate; gradient: 80:20-50:50) to give3-[4-(isopropylcarbamoylmethyl)piperazin-1-yl]-5-phenethyl-1,2,4-triazine (101 mg) as a yellow viscous substance. MS (APCI) 369 [M+H]+
The synthetic route of 2895-21-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; USHIROGOCHI, Hideki; SASAKI, Wataru; ONDA, Yuichi; SAKAKIBARA, Ryo; AKAHOSHI, Fumihiko; (158 pag.)EP3135668; (2017); A1;,
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