Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 456-64-4, name is 1,1,1-Trifluoro-N-phenylmethanesulfonamide, A new synthetic method of this compound is introduced below., SDS of cas: 456-64-4
The free phenolic hydroxy was then triflated to give 39.; Compound 39; To a solution of 38 (324 mg, 1.50 mmol) in CH2C12 (20 mL) at RT, PhNHTf (639 mg, 1.8 0 mmol) was added at once. NEt3 (417 uL, 3.0 mmol) was added dropwise over 5 min. The reaction mixture was stirred at RT for 10 hr. The solvents were removed in vacuo. The residue was purified by silica gel flash chromatography with 6:1 Hex/EtOAc to give the title compound (454 mg, 87%) . XH NMR (400 MHz, CDCI3) : 8, 2.68 (s, 3H) , 3.89 (m, 2H) , 4.70 (d, J = 17.4 Hz, 1H) , 5.20 (d, J = 10.4 Hz, 1H) , 6.03 (m, 1H) , 6.34 (s, 1H) , 7.36 (d, J= 9.2 Hz, 2H) , 7.47 (d, J = 9.2 Hz, 2H) . 13C NMR (100 MHz, CDCI3) : 8, 24.1, 31.3, 117.4, 117.9, 118.8, 120.7, 124.1, 130.8, 134.4, 144.6, 152.3,153.5, 158.8. IR umax(NaCl)/cm-1: 1727, 1428,1216, 1135, 965. MS (APCI+) calculated for C14H11F3O5S ml z 348.30, observed mlz 348.8.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; THE TRUSTEES OF COLLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; WO2006/26368; (2006); A2;,
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