Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22726-00-7, name is 3-Bromobenzamide, A new synthetic method of this compound is introduced below., 22726-00-7
To a tube charged with 3-Bromo-benzamide (180 mg, 0.9 mmol) and Pd(dppf)Cl2 (40 mg, 0.054 mmol), was added 4-Hydroxy-5-methoxy-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzaldehyde (250 mg, 0.9 mmol, Example 160, step d) as a solution in 2 mL of DMF followed by the addition of K2CO3 (248 mg, 1.8 mmol) in 0.5 mL H2O. The tube was sealed with a cap and allowed to heat for 16 hours at 85 C. Reaction mixture was then filtered and purified on reverse phase HPLC. Fractions containing the desired product were combined and the solvent was removed under reduced pressure to yield 82 mg of product 2?-Formyl-5?-hydroxy-4?-methoxy-biphenyl-3-carboxylic acid amide.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Zhou, Jinglan; Robinson, Leslie; Gubernator, Nikolaus M.; Saiah, Eddine; Bai, Xu; Gu, Xin; US2003/225110; (2003); A1;,
Amide – Wikipedia,
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