Application of 106984-09-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 106984-09-2, name is tert-Butyl (2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Sodium hydride (7.2 g, 0.3 mol) was weighed in a three-necked flask,Add 200 ml of tetrahydrofuran, cool to 0 or less,BOC-NH-PEG4 (29.3 g, 0.1 mol) was slowly added dropwise,Control the reaction temperature is about 0 . After 1 hour, continue to cool to -5 ,Slowly dropwise 3-bromopropionic acid (15.3 g, 0.1 mol) was added to control the reaction below 0 ,After the completion of the reaction at room temperature for 24 hours, with dilute hydrochloric acid PH value of 3-4,Ethyl acetate was extracted three times, the combined extracts were dried,Boc-NH-PEG4-CH2CH2COOH (23 g yield 63%) was recovered under reduced pressure.Boc-NH-PEG4-CH2CH2COOH (7.3 g, 0.020 mol) was dissolved in 50 mL of tetrahydrofuran,Slowly add 2mol / L hydrochloric acid solution (20mL),And stirred at room temperature overnight. The next day, add 50mL of ethyl acetate,And then extracted with ethyl acetate water phase once,The water phase evaporated to dry NH2PEG4-CH2CH2COOH hydrochloride crude,And then crystallized from ethyl acetate to give pale yellow crystals(3.92 g, Yield: 65%)
The synthetic route of tert-Butyl (2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)carbamate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chengdu Furuikang Biological Technology Co., Ltd.; Luo Qiandong; Hu Deyin; (7 pag.)CN104774161; (2017); B;,
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