Application of 67442-07-3, These common heterocyclic compound, 67442-07-3, name is 2-Chloro-N-methoxy-N-methylacetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
n-Butyllithium (2.5 M in hexane, 2.58 mL, 6.44 mmol) was added dropwise to a mixture of diisopropylamine (0.87 mL, 6.18 mmol) in Et20 (30 mL) at -10 ¡ãC. After 30 min the mixture was cooled to -60 ¡ãC and a solution of 3-fluoropyridine (0.44 mL, 5.15 mmol) in Et20 (10 mL) was added dropwise at -60 ¡ãC. After 45 min a solution of 2-chloro-/V-methoxy-//- methylacetamide (708.49 mg, 5.15 mmol)l in Et20 (10 mL) was added dropwise at -60 ¡ãC and the mixture was stirred at -60 ¡ãC for 1 h. The cooling bath was removed and NH4CI (aq, 10 percent, 20 mL) was carefully added. The organic phase was collected, diluted with EtOAc, washed with NH4CI (aq, 10 percent), brine, dried (Na2S04), filtered through silica gel and concentrated. The residue was partitioned between H2O and CH2CI2 and the aq phase was washed with CH2CI2. The combined organic phases were dried (Na2S04) and concentrated to give the sub-title compound (750 mg, 4.32 mmol, 84 percent).
The synthetic route of 67442-07-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ATROGI AB; PELCMAN, Benjamin; BENGTSSON, Tore; (93 pag.)WO2019/53427; (2019); A1;,
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