Adding a certain compound to certain chemical reactions, such as: 227940-71-8, name is tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 227940-71-8, Safety of tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
Trifluoro acetic acid (TFA) (2.25ml, 5eq, 0.03 mol) was injected to the stirring suspension of compound 12 (2.0g, l eq, 0.006mol) in DCM at 0C and allowed to stir at 25C (25-35C). Then reaction mixture was made alkaline by adding 20% aq. solution of Na2C03 and resulting mixture was extracted with dichloromethane (3 chi 50ml) and organics were washed with brine. The combined organics were dried with anhydrous Sodium sulphate and concentrated to obtain yellow oily liquid ( 1.641 g). Yield: 90% ; IR(Neat): 3451.4, 2924.6, 1610.0, 1450.4 cm” ;1H NMR (300MHz, CDC13, ppm): 87.37-7.27 (m, 5H, Ph-H); 3.49-3.41 (m, 4H, ChbPh, 2xNCH); 3.31-3.27 (d, J=12Hz, 2H, 2*NCH); 3.19-3.1 1 (m, 2H, 2> NCH); 2.49-2.45 (d, J=12Hz, 2H, 2xNCH); 2.12-2.07 (m, 2H, 2*CH); 1.93- 1.89 (d, J= 12Hz, I H, bridge CH); 1.79- 1.75 (d, J=12Hz, IH, bridge CH); MS (ESI):m/z = 217 (M+H)+
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Reference:
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; DIKSHIT, Dinesh Kumar; KARUNAKARAN SASIKALA, Anil Kumar; DIKSHIT, Madhu; BARTHWAL, Manoj Kumar; MISRA, Ankita; JAIN, Manish; WO2015/44951; (2015); A1;,
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