In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 915087-25-1 as follows. HPLC of Formula: C8H9FN2O
Synthesis of 4-(2-cyano-2-hexadeuteropropylamino)-2-fluoro-N-methyl benzamide (compound 28) TMSCN (2.1 g, 21.2 mmol), compound 5 (0.7 g, 4.2 mmol) and deuterated acetone (1.5 g, 23.4 mmol) were placed in a microwave reaction tube, and the mixture was heated to 80C by microwave, and reacted for 3 h, power 50 W. The mixture was cooled to room temperature, deuterated acetone was removed under reduced pressure, and water was added (20 mL). The resulting mixture was extracted with ethyl acetate, washed with brine, dried over sodium sulfate, and concentrated. The resulting solid was washed with petroleum ether (10 mL) and dried by suction to give compound 28 as a white solid (870 mg, 86.6% yield). 1H NMR (CDCl3, 400 MHz): delta(ppm) 7.98 (1H, t, J = 8.4 Hz), 6.64 (1H, s), 6.62 (1H, d, J = 4 Hz), 6.58 (1H, s), 4.37 (1H, s), 3.00 (3H, s).
According to the analysis of related databases, 915087-25-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; HC Pharmaceutical Co., Ltd.; CHEN, Yuanwei; EP2792674; (2014); A1;,
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