Tf2O-Mediated Intermolecular Coupling of Secondary Amides with Enamines or Ketones: A Versatile and Direct Access to β-Enaminones was written by Liu, Yong-Peng;Zhu, Cheng-Jie;Yu, Cun-Cun;Wang, Ai-E.;Huang, Pei-Qiang. And the article was included in European Journal of Organic Chemistry in 2019.Safety of 4-Formyl-N-isopropylbenzamide This article mentions the following:
Based on the Tf2O-mediated intermol. reaction of secondary amides with enamines derived from ketones, a novel approach to β-enaminones was developed. The reaction is widely functional group tolerant and highly chemoselective. In the presence of 4 Å mol. sieves, the method can be extended to the one-pot condensation of secondary amides with ketones for NH β-enaminones synthesis. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Safety of 4-Formyl-N-isopropylbenzamide).
4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Safety of 4-Formyl-N-isopropylbenzamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics