Pushkareva, Z. V. et al. published their research in Zhurnal Obshchei Khimii in 1954 | CAS: 53297-70-4

4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 53297-70-4

Dipole moments and structure of some sulfanilamide compounds was written by Pushkareva, Z. V.;Kokoshko, Z. Yu.. And the article was included in Zhurnal Obshchei Khimii in 1954.Recommanded Product: 53297-70-4 This article mentions the following:

Dipole moments of several sulfonamides were determined conventionally in dioxane (C6H6 was used as a reference liquid) at 25°; at. polarization was neglected; the electronic polarization (Pe) was calculated from the exptl. value of refraction of PhSO2NH2 (cf. Gur’yanova, C.A. 41, 6786a). The following values of the polarization at infinite dilution (P∞), Pe, and dipole moment (μ × 1018), resp., are reported for PhSO2NHR (R given): H, 571.39, 40.13, 5.09; Ph (m. 109-10°), 595.34, 64.22, 5.07; 3,5-Cl2C6H3 (m. 134-5°), 539.08, 73.85, 4.75; p-H2NSO2C6H4 (m. 148°), 714.82, 78.06, 5.55; Ac (m. 122°, from PhSO2NH2 and Ac2O), 558.14, 49.37, 4.96; 2-pyridyl (m. 171-2°), 573.51, 65.76, 4.95. Also p-H2NC6H4SO2NH2, -, -, 6.60; 3,4-Me(H2N)C6H3SO2NH2 (prepared by sulfonation of o-MeC6H4NHAc at 60-70° with HO3SCl 2 hrs., followed by aqueous NH4OH, yielding the crude amide, m. 202-4°; this heated to 80° in 1:3 H2SO4 1.5 hrs. and the filtrate treated with NH4OH gave the final product, m. 145-6°), 808.14, 48.27, 6.06; 1,4-H2NC10H6SO2NH2 (m. 212°), 943.94, 61.09, 6.53; p-H22NC6H4SO2NHAc (Albucide) (m. 182°), 1030.45, 58.80, 6.88; sulfapyridine (m. 192°), 1189.56, 69.08, 7.2; p-H2NC6H4SO2NHC6H4SO2NH2, 1090.78, 82.58, 6.99. Comparison of the moments so obtained with the vectorial addition of moments indicates an interaction between the p-groups NH2 and SO2NHR, with enhanced moment; no such enhancement exists in the m-derivatives The rotation of the NH2SO2 group is apparently restricted so that the H atom of the amide is located at the least distance from the O atoms of SO2. In the experiment, the researchers used many compounds, for example, 4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4Recommanded Product: 53297-70-4).

4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 53297-70-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics