Production of copper-graphene nanocomposite as a voltammetric sensor for determination of anti-diabetic metformin using response surface methodology was written by Hassasi, Shima;Hassaninejad-Darzi, Seyed Karim;Vahid, Amir. And the article was included in Microchemical Journal in 2022.Application In Synthesis of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide This article mentions the following:
In this paper, application of a sensitive electrochem. technique assisted with multivariate optimization methods is presented for measurement of anti-diabetic metformin (MET) drug in pharmaceutical and serum samples. The sensitive electrochem. sensor was modified carbon paste electrode by copper-graphene nanocomposite (Cu-G/CPE). Firstly, synthesis of graphene (G) and copper-graphene (Cu-G) were performed and X-ray diffraction, field emission SEM, transmission electron microscopy, Fourier transform IR spectroscopy, Raman spectroscopy and N2 adsorption-desorption isotherm were applied to specify the structure of them. Field emission SEM of Cu-G shows carbon sheets were decorated with some dense layer of well-dispersed uniform CuNPs with a type size around 50 nm. Also, the X-ray diffraction pattern of Cu-G displays several peaks for Cu, which approves the formation of Cu-G nanocomposite. Next, the G and Cu-G are used for modification of a carbon paste electrode (CPE) surface. Results from response surface methodol. indicated that solution pH of 12, 11% of Cu-G nanocomposite in the modified CPE, accumulation potential (0.2 V) and accumulation time (80 s) outcomes in the maximal c.d. The electrochem. behavior of MET at the Cu-G/CPE surface are investigated by differential pulse voltammetry (DPV), cyclic voltammetry (CV), and chronoamperometry techniques. The electron-transfer coefficient, catalytic rate constant and diffusion coefficient are found to be 0.84, 6.27 x 106 cm3 mol-1 s-1 and 1.07 x 10-8 cm2 s-1, resp. Under the optimum conditions, the detection limit and linear dynamic range were found to be 3.4μM and 10.4-1125.0μM by DPV technique, resp. The Cu-G/CPE exhibited good reproducibility, stability and high recovery and it has low cost, low background current, ease of surface renewal. The Cu-G/CPE has better poisoning tolerance ability than bare CPE for electro-oxidation of MET and is a superior sensor for the long-term action. Furthermore, the proposed method can be applied as a valorous anal. method in the quality control of the pharmaceutical industry. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Application In Synthesis of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide).
5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Application In Synthesis of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics