Reactions of OH-radicals with procarbazine. A pulse radiolysis and computer simulation study was written by Delipetar-Grudl, A.;Solar, S.;Getoff, N.. And the article was included in Anticancer Research in 2006.Recommanded Product: 13255-50-0 This article mentions the following:
Pulse radiolysis was applied to study the reactivity of ·OH radicals with procarbazine (PC), a cytostatic agent widely used in radiation- and chemotherapy. An overall rate constant of k(·OH+PC)=3.7×109 l.mol-1.s-1 was determined The thereby formed transients had a strong absorption at 350 nm, ε350=4.46×103 l.mol-1.cm-1, and a weak absorption band around 530 nm. Computer simulation studies to elucidate the most probable sites of ·OH attack on the PC mol. showed that ·OH radical addition to the aromatic ring had the highest probability. These transients decayed by a first order reaction, k=1.75×103 s-1, whereby species having a maximum absorption at 300 nm and broad shoulder at 340-380 nm were formed. Similar absorptions were observed after gamma radiolysis of PC. A reaction mechanism is suggested. For the reaction of H-atoms with PC, a rate constant k(·H+PC)=6.4×108 l.mol-1.s-1 was determined In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Recommanded Product: 13255-50-0).
4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 13255-50-0
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics