Salicylamide in urine after intake of acetylsalicylic acid due to degradation of salicylic acid conjugates was written by Besserer, Kurt;Tiess, Detlef;Kala, Maria. And the article was included in Z Zagadnien Nauk Sadowych in 2000.Recommanded Product: N,N-Diethylsalicylamide This article mentions the following:
In addition to the well-known acetylsalicylic acid metabolites, salicylamide (SA) was detected in urine from healthy persons after intake of acetylsalicylic acid. SA was found in the Et2O extracts of urine after alkalinization by ammonia solution SA was identified by gas chromatog.-mass spectrometry. Further examination showed that SA was present in urine only after alkalinization by ammonia solution and not after alkalinization by NaHCO3 or Na2CO3. When dimethyl-, diethyl- or dibutylamine was used for the alkalinization of the urine, the corresponding salicylic acid dialkylamides were detected. Further anal. led to the conclusion that ester-type salicylic acid glucuronide conjugates undergo degradation by hydrolytic amination to form the corresponding amides. This gives the possibility of a specific demonstration of the presence of ester-type glucuronide conjugates. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Recommanded Product: N,N-Diethylsalicylamide).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Recommanded Product: N,N-Diethylsalicylamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics