Electric Literature of 112434-18-1, The chemical industry reduces the impact on the environment during synthesis 112434-18-1, name is Benzyl (2,4-difluorophenyl)carbamate, I believe this compound will play a more active role in future production and life.
Step 2 – Preparation of (2,4-difluoro-3-formyl-phenyl)-carbamic acid benzyl ester (33):[0230] In a round bottom flask (2,4-difluoro-phenyl)-carbamic acid benzyl ester (30, 3.83 g, 14.5 mmol) is combined with 148 mL of tetrahydrofuran. The solution is chilled to -78 C and n-butyllithium (19.1 mL, 1.60 M in hexane, 30.0 mmol) is added over 30 minutes, followed by the addition of N,N- dimethylformamide (1.12 mL, 14.5 mol). The reaction mixture is allowed to warm to ambient temperature and is stirred overnight, then poured into water and extracted with ethyl acetate. The organic layer is washed with brine, dried over sodium sulfate, filtered and the filtrate concentrated under vacuum. The resulting material is crystallized from ether to provide the desired compound (33, 3.0 g, 71%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Benzyl (2,4-difluorophenyl)carbamate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PLEXXIKON, INC.; IBRAHIM, Prabha, N.; SPEVAK, Wayne; CHO, Hanna; SHI, Songyuan; ZHANG, Chao; ZHANG, Ying; WO2011/63159; (2011); A1;,
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