19F-{1H} NMR study of exchange equilibriums with participation of sulfonamides and their phenylmercuric derivatives in DMSO was written by Kravtsov, D. N.;Peregudov, A. S.;Ivanov, V. F.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1983.Name: N-Isopropylbenzenesulfonamide This article mentions the following:
Equil constants (K) were determined for exchange of the PhHg group between 4-PhSO2N(HgPh)C6H4R (I; R = H, F) and PhSO2NHR1 (II; R1 = alkyl, Ph, substituted phenyl). The following relation was obtained for exchanges between I (R = H) and II (R1 = m– and p-substituted phenyl): log K = -0.27 pKa + 3.46. Deviation from this equation were found for II with steric and intramol. coordination interactions. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Name: N-Isopropylbenzenesulfonamide).
N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Name: N-Isopropylbenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics