Related Products of 5349-24-6, These common heterocyclic compound, 5349-24-6, name is N-Butyl-2-chloroacetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Compound 1,2,4-triazol-3-thiol (4) (0.01 mol) was dissolved in aqueous potassium hydroxide solution (0.61g in 100 ml distilled water) with stirring till a clear yellow color solution was obtained. It was filtered to remove any suspended impurities. Then various N-substituted-alpha-chloroacetanilides (0.01 mol) compound were dissolved in ethanol and added with shaking at 55C stirred for 4.5 h. Then the reaction mixture was left overnight and the next day, the separated solid was filtered and washed twice with cold distilled water to remove KCl, dried and recrystallized from dilute glacial acetic acid. In case of aliphatic N-substituted-alpha-chloroacetanilides, the amide was added at room temperature.
The synthetic route of 5349-24-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Rajoriya, Vaibhav; Kashaw, Varsha; Kashaw, Sushil K.; Letters in drug design and discovery; vol. 15; 5; (2018); p. 451 – 462;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics