Dereli, Dilara Basat et al. published their research in Journal of the Iranian Chemical Society in 2022 | CAS: 10238-21-8

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Safety of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide

Determination of the ionization constants of sulfonylureas in THF-water media by potentiometric titration and RPLC methods was written by Dereli, Dilara Basat;Alsancak, Abbase Guleren. And the article was included in Journal of the Iranian Chemical Society in 2022.Safety of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide This article mentions the following:

In this study, the ionization constants (pKa) of sulfonylurea group antidiabetic drugs (glibenclamide, gliclazide, glimepiride, and glipizide) were calculated, providing significant information about the physicochem. properties of the drugs. Potentiometric titration and reverse-phase liquid chromatog. were used to determine the ionization constants in THF-water media. The PKPOT and NLREG computer programs were used to evaluate the results. In addition, the aqueous pKa values of the compounds were calculated using the Yasuda-Shedlovsky equation and mole fraction-pKa extrapolation methods. When the potentiometric titration method was used, the aqueous pKa values of glibenclamide, gliclazide, glimepiride, and glipizide were calculated to be 6.002, 6.085, 6.106, and 6.016, resp., using the Yasuda-Shedlovsky equation, while the mole fraction-pKa extrapolation method gave 6.013, 6.096, 6.117, and 6.027, resp. On the other hand, when the RPLC method was used, pKa values of 5.489, 5.732, 5.733, and 5.601, resp., were obtained with the Yasuda-Shedlovsky equation and mole fraction-pKa extrapolation gave 5.499, 5.742, 5.743, and 5.611, resp. The ionization constants obtained with these methods provide valuable information for researchers studying these active pharmaceutical compounds In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Safety of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Safety of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics